Reportedly, Poederia foetida locally known as ‘kantutai’ has long been used in traditional medicine in the Philippines in the treatment of rheumatism, ulcers, diarrhea, dysentery, inflammation of the spleen, indigestion and flatulence. However, these reports were anecdotal, thus the need to provide scientific basis to traditional healing practices of marginalized and geopgraphically isolated communities. This study aimed to investigate the antimicrobial properties of P. foetida extracts from stems and leaves against S. aureus, E. coli, and C. albicans. The extracts exhibited antimicrobial activity against bacteria but not against the fungus. Ethyl alcohol extracts showed larger inhibition zones compared to ethyl acetate extracts. Phytochemical screening revealed the presence of alkaloids, saponins, and tannins. Further research is suggested to optimize extraction protocols and explore the full potential of P. foetida as an antibacterial agent.