This research explores the use of water-soluble biocompatible polymers, guar gum (GG) and methyl cellulose (MC), alongside the nanomaterial maghemite (γ-Fe2O3), for transdermal sustained drug release, employing metoprolol succinate as a model drug. Drug-infused thin film patches of GG, MC, their γ-Fe2O3 nanocomposites, and 10/90 GG/MC blend - γ-Fe2O3 nanocomposites were utilized for the investigation. Physicochemical parameter evaluations, including thickness, weight, folding endurance, % moisture absorbance, and % moisture loss, supported the drug release kinetics study using a hydrated cellophane sheet and diffusion tube. The results indicate that this blend-nanocomposite system releases the drug through diffusion, following Fickian kinetics. These biomaterials hold promise for developing slow, sustained release formulations in transdermal drug delivery systems.