Introduction: Various strategies have been implemented by healthcare organizations to enhance medication safety. This review aims to comprehensively review evidence on established and emerging best practices for medication safety, their impact on patient outcomes, and challenges associated with implementation.The findings are discusses under key themes of medication safety protocols, pharmacist involvement, clinical decision support systems, computerized physician order entry, barcode medication administration, and recent advancements. Methodology: A comprehensive search of databases including PubMed, MEDLINE, and Google Scholar was conducted using keywords such as "medication safety," "medication errors," "medication management," and "healthcare facilities." The search was limited to articles published between 2010 and 2021 to ensure the inclusion of recent research. The selected studies were critically reviewed, and relevant findings were synthesized to provide a comprehensive overview of the topic. Results: Numerous organizations, such as the Institute of Medicine (IOM) and the World Health Organization (WHO), have emphasized the importance of medication safety in healthcare facilities. The implementation of standardized medication safety practices, including medicationreconciliation, barcode scanning, and computerized physician order entry (CPOE), has been shown to reduce medication errors and improve patient outcomes. Advancements in technology have played a significant role in enhancing medication safety. Electronic prescribing systems, automated dispensing cabinets, and smart infusion pumps have demonstrated effectiveness in reducing medication errors and improving medication administration accuracy Medication Reconciliation is crucial for preventing medication discrepancies and errors. The implementation of CDSS has shown promising results in reducing medication errors andimproving prescribing practices. Increased pharmacist participation in medication reconciliation was found to reduce discrepancies by 20-70% compared to nursing or physician reconciliation alone. They rounding on patients and addressing drug therapy problems as part of multidisciplinary teams can also help optimize medication management and reduce errors. Discussion: The review indicates established medication safety strategies have demonstrated benefits in reducing errors and adverse events when implemented comprehensively. However, barriers persist including resource requirements for personnel, technology infrastructure and training. Sustained engagement of leadership, clinicians and frontline staff is also important for successful, long-term change management. More research is still needed to fully understand realworld impact and unintended consequences of these newer approaches. Standardization of best practices and interoperability across healthcare systems also remain areas for improvement to optimize patient handoffs and care coordination. However, challenges persist regarding resources, workflows and sustained engagement. Emerging technologies also show promise but require further evaluation. Overall, a systematic, tailored approach with regular assessment and refinement seems most prudent to optimize safe medication use across care settings. With leadership commitment and a culture of safety, the goal of preventing medication-related harm can continue advancing.