Construction industry uses Cement vividly to meet the demand towards infrastructure development. The type of cement paste formed during reaction of cement with water to produce durable products is very important to sustain in chemical environments. Several industrial by-products produced can be conveniently replaced in concrete to meet such needs of the contruction industry. Stone dust or powder is available in Kadapa slab, marble and barite industries. To improve the serviceability and sustainability against chemical environment, cement is partially replaced by various fractions of powders, barites(15%), marble(15%) and Kadapa slab(10%). Investigations have been made on the performance of cement mortar submerged in, sulfuric acid (H2SO4), hydrochloric acid(HCL), Potassium Hydroxide(KOH) and Sodium Hydroxide(NaOH) solutions. All the cement mixes were cured in these solutions for 56 days and determined their compressive strength and density along with conventional cement mortar for comparison. The cement mortar made with 15% replacement by barites powder in cement attained better compressive strength and density in comparison with other cement replacement materials. Also cement mortar offers high resistance against hydrochloric acid (HCL) impact in comparison with the impact of other chemicals.