Background: Through this research work we determine the particle of calcium carbonate in 1X and 2X by FTIR Methodology: prepared the Calcarea carbonicum 1x and 2x by the trituration with decimal scale, ex: 1 part of drug mixed in 9 parts of sugar of milk for preparing 1x, thereafter same procedure followed for prepare 2X Potency of Calcarea carbonicum by taking 1 part of previous potency 1X mixed with the sugar of milk. Afterwards take 1 part of each sample place over the FTIR (Fourier transform infrared spectroscopy) for determine the particle of calcium carbonate at different wavelength in 1X and 2X Potency. Results: Identifying the calcium carbonate and calcite at 1431 nm, 869 nm, 307 nm (Wavlength) in 1X and 2X.