It is the first strong cation exchange chromatography estimation of Ivabradine and Metoprolol. Several studies have examined Ranolazine and Dronedarone together. No one has revealed their UV sensitivity. The reported methods were further challenging because they required sophisticated elution to estimate both medications simultaneously. Their analysis time was long, increasing solvent consumption and analysis time. As a result, the simultaneous estimation of Ivabradine and Metoprolol carried out at 223 nm with resolution (R) and capacity factor (k) which were both within acceptable ranges. This whole process took around 10 minutes. Thus, UltraSil-MCX column eluent compositions, buffers, and elution modes were explored to increase specificity and selectivity. Isocratic elution with 10mM ammonium formate (AF)-methanol (20:80 v/v) for 10 minutes with considering isocratic elution at 1.2 ml/minute flow rate. The proposed method is validated as per the guidelines.