Post-operative wound infection is a very serious problem, leading to a risk of significant morbidity which may even lead to prolonged hospitalization. The present study was conducted to evaluate role of vacuum assisted closure therapy in chronic wounds. Materials & Methods:80 patients of chronic wounds of both genders were selected. A thorough local examination was carried out. Procedure involves wound preparation, placement of white foam (PVA - Polyvinyl alcohol) & black foam; sealing with drapes and application of pressure. Parameters such as size of wound, etiology, Gustilo Anderson classification and bacterial growth was recorded. Results: Out of 80 patients, males were 50 and females were 30. The size of wound was 1- 4.9 mm in 20, 5-9.9 mm in 35 and >10 mm in 19 patients. Etiology was RTA in 52, machinery injury in 15 and fall from height in 7 cases. Gustilo Anderson classification grade IIIb was seen in 41, grade IIIc in 25, grade IIIa in 5 and grade II in 3 cases. Bacterial growth on day 0 was seen in 74, on day 4 in 56 and on day 8in 28 patients. The difference was significant (P< 0.05). Conclusion: Vacuum assisted closure therapy is preferred treatment of wounds. It has less overall morbidity with decreased hospital stay.