An Oro-antral fistula (OAF) refers to an aberrant pathological communication between the oral cavity and the maxillary sinus. This anomalous conduit with the maxillary sinus often manifests during select surgical interventions in the posterior maxillary region. The most common cause of this condition is known to be an extraction of posterior maxillary teeth and dental implant surgery. If left untreated, it progresses to maxillary sinusitis and impairs the quality of life of the patient. OAF can be managed by creating a barrier between the oral cavity and maxillary sinus. This article includes the patient history, clinical examination, diagnostic criteria, management strategies, and prognosis of Oro-antral fistula.