There is wide range of operation and processes as diverse as its products in pharmaceutical industries and effluents generated from these processes vary from one industry to other. As these processes consumes variety of toxic chemicals, the effluents generated are complex in nature and are not easily treatable by the conventional methods of treatment. The current study has been undertaken to evaluate techno economically clean technologies with in process which are resulting into pollution load reduction at the end pipe of treatment and reduction in emissions. Presently in most of the extraction processes conventional methods such as solvent extraction, steam distillation and hot water extraction etc are involved. However due to stricter environmental regulations use of green technology replacing conventional extractions methods is gaining momentum. The industry selected for study is manufacturing Colochicine and Thiocolochocide by processing Gloriosa Superba seeds, a herb traditionally used for treatment of various clinical conditions like inflammation, edema, skin infections and many others. Accordingly the aim of the paper is to present work ability of replacing conventional solvent extraction with super fluid CO2 extraction up to syrup stage with in process and environment friendly techniques. Being a green solvent the effect on herbal extraction suggests the use of pressure and temperature in the range of 350mm-450mm and temperature up to 65oC respectively. The major components of extracted material were identified as syrup and has been has further subjected to purification and crystallization besides resulting into 60% reduction in case of waste water generation per kg of product and same level of reduction in SO2 emissions from sources using the pet coke or coal as fuel.