In the field of nursing, preventing infections in operating rooms is of critical importance. This literature review aims to analyze and summarize existing research on effective strategies to avoid infections in operating rooms from the perspective of nursing at the master's level. By examining a range of reputable journal articles, this review identifies and evaluates specific interventions, protocols, and guidelines that can enhance patient safety in surgical settings. The analysis suggests that a combination of strict adherence to infection control practices, proper hand hygiene, appropriate antimicrobial prophylaxis, and education and training play pivotal roles in reducing the risk of infections. The significance of this review lies in its potential to inform nursing practice and contribute to the ongoing improvement of infection prevention in operating rooms.